Senior Director, Dosimetry and Radiobiology Physicist

This is a fully remote position, open to applicants in California.

📋 Description

• Lead and oversee internal dosimetry, including absorbed dose calculations and dose-response assessments for radiopharmaceutical imaging and therapeutic agents.

• Design and implement dosimetry strategies for both preclinical and clinical research.

• Create dosimetry protocols, workflows, imaging-to-dose analysis plans, uncertainty assessments, and clinical trial documentation.

• Direct patient-level dosimetry utilizing PET, SPECT, and CT, which includes voxel-level and Monte Carlo-based dose calculations.

• Employ time-activity integration, pharmacokinetic and compartmental modeling, as well as translating dosimetry from animals to humans.

• Develop multi-scale dosimetry methodologies across organ, voxel, cellular, and sub-cellular levels, especially for alpha-emitting radiotherapeutics.

• Collaborate with biology and translational teams to link absorbed dose to biological response, optimizing dose selection, combination strategies, and therapeutic windows.

• Ensure quality control, standardization, calibration, physical validation, and quality assurance of dosimetry data.

• Introduce new dose calculation platforms and modeling techniques for innovative radioisotopes.

• Maintain relationships with software vendors, CROs, external researchers, academic partners, and government entities.

• Represent the organization in professional societies, standards committees, and collaborative groups.

• Offer technical support, training, and mentorship to cross-functional teams.

• Contribute to regulatory filings and the advancement of medical physics knowledge.

• Articulate complex dosimetry, radiation transport, and radiobiology subjects to scientific audiences.

• Organize and deliver work in accordance with corporate deadlines with minimal oversight.

• Uphold professional ethics, integrity, leadership, confidentiality, and stay current with dosimetry guidelines.

• Utilize AI to enhance program, portfolio, or functional performance through prioritization and widespread adoption.

⛳️ Requirements

• Advanced degree in Medical Physics, Nuclear Engineering, or a related field, with formal training in radiation transport and internal dosimetry.

• At least 10 years of experience managing radiopharmaceutical dosimetry programs in academic, clinical, or industry contexts.

• Minimum of 5 years of experience in dosimetry for radiopharmaceutical therapies within oncology, covering both preclinical and clinical applications.

• A PhD in Medical Physics, Nuclear Engineering, or a related discipline is preferred.

• Acknowledged professional reputation in the radiopharmaceutical therapy dosimetry community is preferred.

• Extensive experience in radiopharmaceutical therapy dosimetry for oncology, including theranostic pairs and technologies involving alpha-, beta-, and Auger-emitter.

• Proficiency in designing, executing, and analyzing dosimetry studies in preclinical and clinical settings.

• Experience in validating image-based dosimetry processes against physical measurements and ensuring data quality control and standardization.

• Profound expertise in Monte Carlo radiation transport and patient-specific dose calculations.

• Familiarity with dosimetry platforms, heterogeneous GPU/CPU computing, and multi-scale dosimetry.

• Working knowledge of radiation biology, dose-response dynamics, radiobiological modeling, and combination therapy effects.

• Technical skills in OLINDA, MIRDcalc, MIM, Torch/RAPID, GATE, Geant4, MCNP, SIMIND, 3D Slicer, ITK-SNAP, Elastix, Python, C/C++, Matlab, or R.

• Experience in deformable registration and segmentation processes.

• Proven ability to manage cross-functional projects and align various stakeholders.

• Demonstrated success in mentoring and developing technical personnel.

• Capability to work efficiently with minimal supervision in a fast-paced environment.

• Strong communication abilities for diverse scientific audiences, regulatory agencies, vendors, and internal stakeholders.

• Willingness to travel up to 30% of the time.

• Ability to work in a laboratory setting with appropriate protective gear, including clothing, gloves, and safety glasses when handling radioactive materials.

🏝️ Benefits

• Additional discretionary incentive cash.

• Stock opportunities.

• Wellbeing support.

• Retirement and financial protection benefits.

• Medical, dental, vision, life, and disability insurance options.

• Flexible Time Off (FTO) without an accrual limit for eligible U.S.-based exempt employees.

• 11 paid company holidays each year.

• 160 hours of paid vacation annually for new hires for eligible non-exempt, RayzeBio, and Puerto Rico employees.

• 3 optional holidays for eligible non-exempt, RayzeBio, and Puerto Rico employees.

• Paid sick leave, subject to eligibility.

• Up to two paid volunteer days per year.

• Summer hours flexibility.

• Medical, personal, parental, caregiver, bereavement, and military leaves of absence.

• Annual Global Shutdown between Christmas Day and New Year's Day.

• Reasonable workplace accommodations and ongoing support.