Medicinal Chemistry, Drug Discovery Scientist

This is a fully remote position, open to applicants in New York.

📋 Description

• Develop realistic and technically complex research challenges in drug discovery and development.

• Create tasks that necessitate the integration of incomplete, indirect, or potentially misleading scientific data.

• Formulate scientifically defensible conclusions that are supported by the available evidence.

• Compile structured data repositories utilizing real, source-validated scientific information.

• Ensure that critical values, observations, and experimental findings are traceable to reliable sources.

• Build evidence chains that lead to defensible conclusions while maintaining scientific integrity.

• Address issues related to structure-based medicinal chemistry, mechanistic enzymology, structure-guided peptide or antibody design, and fragment-based discovery.

• Assess molecular structure, binding, activity, selectivity, optimization, molecular interactions, mechanisms, kinetics, inhibition, binding evidence, structural interpretation, and compound advancement.

• Develop comprehensive grading documents and objective criteria for research-related challenges.

• Conduct verification and calibration, identify shortcuts or ambiguities, evaluate task complexity, and refine assignments.

• Act as a subject-matter expert for scientific and difficulty-related decisions.

• Review feedback, revise materials, defend scientific conclusions, and uphold stringent standards across prompts, evidence packages, and grading materials.

⛳️ Requirements

• PhD or equivalent industry experience in medicinal chemistry, biochemistry, chemical biology, structural biology, pharmaceutical sciences, or a closely related field.

• Extensive working knowledge in at least one of the following: mechanistic enzymology; structure-guided peptide or antibody design; fragment-based drug discovery; structure-based medicinal chemistry.

• Significant experience in interpreting intricate experimental evidence within drug discovery research.

• Capability to construct scientific problems whose conclusions can be rigorously substantiated.

• Strong judgment in assessing the quality of scientific reasoning, not just final outcomes.

• Comfortable with complex, incomplete, and potentially conflicting scientific information.

• Excellent research, analytical, and technical writing abilities.

• Ability to work independently and take responsibility for the quality of scientific tasks.

• Proficient in utilizing browser-based research and development tools.

• Minimum commitment of 20 hours per week required.

• Work must be conducted without utilizing confidential or proprietary information from any employer, client, institution, or other third party.

• H1-B and STEM OPT support is not available for this position.

🏝️ Benefits

• Reimbursement for required project-specific software or subscription access where applicable.

• Project timelines may be extended, shortened, or concluded based on project requirements and performance.

• Fully remote working arrangement.

• Part-time schedule with a minimum of 20 hours per week and the opportunity for up to 40 hours per week.