Senior Manager, Portfolio Analytics – Strategy

This is a fully remote position, open to applicants in California.

📋 Description

• Lead the analysis of portfolios, track performance, and benchmark across the R&D portfolio.

• Own and enhance Amgen’s Probability of Technical and Regulatory Success (PTRS) process.

• Facilitate enterprise-level PTRS evaluations in collaboration with Product Teams and cross-functional experts.

• Develop PTRS methodologies, standards, benchmarks, guardrails, governance cadence, and documentation.

• Oversee PTRS and risk-assessment tools, data products, evidence workflows, dashboards, and decision-support capabilities.

• Collaborate with Product Teams to evaluate risks across product profiles, indications, populations, biomarker strategies, and clinical development options.

• Facilitate discussions based on evidence and clarify assumptions, risks, trade-offs, and decision criteria.

• Support portfolio reviews, prioritization, and investment decisions.

• Lead tracking of portfolio performance and participation in industry benchmarks across development KPIs.

• Provide decision-ready insights for Product Teams, Governance, and senior leadership.

• Ensure consistency across PTRS, valuation, planning, and governance assumptions.

• Utilize historical outcomes, internal performance trends, and external benchmarks to refine assessments and enhance decision quality.

• Collaborate with Technology, Research, Development, Product Teams, and other cross-functional partners.

⛳️ Requirements

• Doctorate degree with 2 years of experience in R&D portfolio management, portfolio analytics, life sciences, or management consulting, or leading decision analysis initiatives; OR

• Master’s degree with 4 years of relevant experience; OR

• Bachelor’s degree with 6 years of relevant experience; OR

• Associate’s degree with 10 years of relevant experience; OR

• High school diploma/GED with 12 years of relevant experience.

• An advanced degree in business, life sciences, medicine, statistics, decision sciences, or a related field is preferred.

• 5+ years of experience in relevant R&D portfolio management, portfolio analytics, life sciences, management consulting, or decision analysis initiatives is preferred.

• Familiarity with decision analysis methodologies and probabilistic modeling techniques, such as decision trees, Monte Carlo simulation, and risk modeling.

• Experience in facilitating PTRS, probability of success, or similar development risk assessments with cross-functional subject matter experts.

• Comprehensive understanding of the entire drug development process and the scientific, clinical, regulatory, CMC, operational, and competitive risk factors involved.

• Comfortable utilizing AI-enabled tools and analytical capabilities for evidence synthesis, risk assessment, insight development, and decision support.

• Strong analytical and strategic thinking abilities.

• Executive presence along with outstanding communication skills.

• Capability to thrive in a fast-paced, ambiguous, and highly matrixed environment.

🏝️ Benefits

• Comprehensive employee benefits package.

• Retirement and Savings Plan with generous company contributions.

• Group medical, dental, and vision coverage.

• Life and disability insurance.

• Flexible spending accounts.

• Discretionary annual bonus program.

• Stock-based long-term incentives.

• Award-winning time-off plans.

• Flexible work models where possible.

• Career development opportunities.

• Work/life balance support.

• Collaborative culture.

• Reasonable accommodation for disabilities.