Principal – AD Medicinal Chemist

This is a fully remote position, open to applicants in United States.

📋 Description

• Oversee and enhance small molecule drug discovery initiatives from initial hit identification to IND-enabling studies.

• Supervise tasks executed at contract research organizations (CROs).

• Suggest and autonomously advance medicinal chemistry strategies from hit identification to lead optimization and development candidate selection.

• Spearhead chemistry activities within multi-disciplinary teams that include bench biologists, DMPK, non-clinical toxicology, computational science, and ML engineering.

• Create, prioritize, and direct the synthesis of innovative compounds utilizing structure-based and ligand-based methodologies.

• Enhance potency, selectivity, pharmacokinetics, and developability of compounds.

• Analyze and synthesize SAR, structural biology, DMPK, pharmacology, and safety data.

• Incorporate AI-driven and computational modeling insights into compound design methodologies.

• Mentor both internal chemists and external partners.

• Oversee external CRO collaborations to ensure high-quality and timely chemistry outcomes.

• Articulate program strategies, data, risks, and recommendations to senior management.

• Write and contribute to patent strategies and applications, scientific publications, and internal documentation.

⛳️ Requirements

• PhD in Organic Chemistry or a related discipline with 3-8 years of relevant industry experience in medicinal chemistry.

• Proven history of advancing drug discovery projects through critical milestones (Hit-to-Lead and Lead Optimization).

• In-depth expertise in synthetic organic chemistry, including contemporary methods and reaction mechanisms.

• Significant experience in structure-based and ligand-based drug design.

• Demonstrated ability to enhance compounds for potency, selectivity, and DMPK/safety characteristics.

• High levels of creativity, productivity, and independent problem-solving skills.

• Experience in managing external CROs and collaborating across various disciplines.

• Outstanding communication skills, capable of clearly conveying complex scientific concepts.

• Experience with small molecule degraders and proximity-inducing chemistry (Nice-to-Have).

• Familiarity with integrating computational chemistry, machine learning, or AI-driven design into medicinal chemistry processes (Nice-to-Have).

• Background in predictive toxicology or ADMET modeling (Nice-to-Have).

• Previous contribution to IND-enabling studies or clinical candidate selection (Nice-to-Have).

• Awareness of modern data science tools and cheminformatics platforms (Nice-to-Have).

• Candidates must be authorized to work for any employer in the U.S.; employment visa sponsorship is not available.

🏝️ Benefits

• Competitive compensation aligned with market standards.

• Equity participation reflecting long-term contributions.

• Remote-friendly culture across both Europe and the U.S.

• Flexible work structure allowing for collaboration across time zones.