AI Biologist – Structural Biology

This is a fully remote position, open to applicants in California.

📋 Description

• Develop expert reasoning and craft exemplary responses for structural biology inquiries.

• Create realistic scenarios involving data collection, processing, map interpretation, model construction, validation, assembly, state assignment, comparison, functional analysis, interaction studies, molecular dynamics, and metadynamics.

• Curate datasets that encompass X-ray, cryo-EM, atomic models, AlphaFold, molecular dynamics, NMR, SAXS, HDX-MS, cross-linking, and SHAPE/DMS techniques.

• Construct Python analysis pipelines utilizing gemmi, Biopython/biotite, and numpy.

• Collaborate with software engineers to develop benchmark workflows.

• Evaluate agents for artifacts, over-interpretation, incorrect interfaces, register shifts, mirrored maps, misdocked domains, and improper use of B-factors or occupancies.

• Resolve ambiguous structural cases and discern the evidence necessary to clarify them.

• Assess representations and comparisons, including biological assemblies, asymmetric units, reference states, and domain superposition.

• Challenge agent reasoning and address scientifically unfounded conclusions.

• Detect agent errors and provide expert alternatives.

• Evaluate agent confidence and appropriately reward uncertainty.

⛳️ Requirements

• PhD in structural biology, biophysics, biochemistry, or a related discipline.

• Practical structural experience in building and validating models.

• Extensive expertise in at least one area: X-ray crystallography, cryo-EM, NMR/solution methods, or computational structural biology.

• Proficient understanding of other structural biology techniques.

• Capability to compute contacts, superpositions, symmetry mates, map values, and geometry from files without a graphical user interface.

• Programming experience related to structural data.

• Regular use of Claude, Cursor, or similar AI agents.

• Ability to discern scientifically unsound AI reasoning.

• Skill in calibrating confidence and conveying uncertainty.

• US citizenship, permanent residency, or OPT-holder status required.

• No STEM OPT extension or sponsorship support provided.

🏝️ Benefits

• Guaranteed pay for the first four weeks during the ramp-up period.

• Unlimited earning potential.

• Full-time employment on a flexible schedule.

• Daily catered lunch and dinner for onsite employees.

• Office located on the waterfront in Mission Bay.

• Monthly parking available when applicable.

• Company outings held most months.

• Team off-site activities.

• Opportunities for latch run club, cycling, boxing, ice skating, and soccer.

• Possibility to transition across teams.

• Potential for swift advancement into senior positions.