Senior/Staff Bioinformatics Engineer, Clinical Applications

This is a fully remote position, open to applicants in United States.

📋 Description

• Implement curation workflows that support both classical and modern AI/ML methods for variant classification.

• Automate the integration of evidence from ClinVar, gnomAD, PubMed, and various other sources.

• Work collaboratively with scientists, product teams, and clinical stakeholders to fulfill scientific and product requirements.

• Guide AI coding agents to expedite the development of the curation pipeline.

• Ensure correctness, security, and architectural compatibility before deployment.

• At the Senior level, take ownership of defined projects from start to finish and make technical decisions aligned with established priorities and architecture.

• At the Staff level, define ambiguous challenges, establish technical direction, and make decisions regarding architecture and prioritization across the product area.

• Engage in onboarding, training, project ownership, and OKR development during the initial 90 days.

⛳️ Requirements

• A Bachelor's degree in Science or a related field with a minimum of 7 years (Senior) or 9 years (Staff) of professional software development experience, or a Master's or Ph.D. with at least 3 years (Senior) or 5 years (Staff) of professional software development experience.

• Advanced expertise in production-quality Python, relational databases, and cloud platforms such as AWS.

• Proven experience in productionizing and scaling AI/ML software, particularly agentic systems developed using frameworks like LangChain or LangGraph.

• Experience working with scientists to incorporate bioinformatics/NGS tools and databases into production workflows.

• Strong judgment in evaluating AI-generated code and pipeline logic for accuracy, security, and maintainability prior to production use.

• Background in clinical genomics, such as familiarity with ACMG guidelines, clinical diagnostics, or HPO terms, is advantageous.

• Experience in developing regulated software, including software as a medical device, is beneficial.

• For the Staff level, experience in mentoring or managing others, or a desire to grow as a people leader, is a plus.

🏝️ Benefits

• Comprehensive Health Insurance with eligibility starting on the Date of Hire.

• Above-average employer-paid premium coverage.

• 12 weeks of Helix Paid Parental Leave available.

• 401(k) plan with employer matching up to 3% and 100% vesting on the Date of Hire.

• Extensive Well-Being Benefits.

• Flexible Paid Time Off (PTO).

• Remote work options for many roles and a stipend for home office setup.

• Equity opportunities.

• Discretionary annual bonus: 15% for Staff and 10% for Senior based on annual salary.