Principal Scientist, Medical Physicist

This is a fully remote position, open to applicants in United States.

📋 Description

• Utilize expertise in radiopharmaceutical-specific modeling for the research and development of innovative drugs and therapies.

• Conduct radiopharmaceutical dose modeling and evaluate in vitro and in vivo data from clinical diagnostic and therapeutic studies.

• Lead analyses in translational dosimetry, including physiologically based pharmacokinetic and compartmental modeling.

• Offer technical assistance, perform dosimetry calculations, provide training, and develop problem-solving solutions for cross-functional teams.

• Collaborate effectively with internal stakeholders, external vendors, and subject-matter experts.

• Aid in internal dosimetry analysis to facilitate the discovery and development of radiopharmaceutical imaging and therapeutic agents.

• Design experiments and assess dosimetric data from PET and SPECT imaging to evaluate drug uptake and distribution.

• Provide guidance on best practices and standardization for quality control of image data in preclinical research.

• Analyze both preclinical and clinical imaging data to enhance animal-to-human dose projection.

• Investigate new technologies and modeling methodologies, including innovative radioisotopes like alpha-emitters.

• Contribute to the body of knowledge in medical physics regarding radiopharmaceuticals.

• Leverage AI to enhance team execution and decision-making processes.

⛳️ Requirements

• Advanced degree in Medical Physics or Engineering, with formal training in RPT biodistribution, kinetics, and dose modeling; a PhD is preferred.

• A minimum of 6 years of experience in molecular imaging and RPT dose modeling research, or 3 years with substantial RPT-specific publications (10+).

• Significant experience with radiopharmaceuticals as therapeutic agents in oncology is highly desired.

• Experience with alpha-emitters is strongly preferred.

• Recognized as a Subject Matter Expert in mathematical pharmacokinetic modeling and its application in radiopharmaceutical research and development.

• Proficient in dosimetry software, coding, and simulation/modeling/statistical tools, including 3D-RD-S, MIM, MIRDcalc, OLINDA, Torch, GATE, SIMIND, SAAM II, SimBiology, Python, Matlab, R, SPSS, ITK-snap, 3D slicer, and Elastix.

• Strong communication skills with the ability to think creatively when addressing challenges in multidisciplinary projects.

• Proven history of coordinating and aligning cross-functional stakeholders to meet corporate timelines in a collaborative environment.

• Excellent verbal and written communication skills, capable of presenting and discussing imaging and dosimetry topics clearly and concisely, including with global scientific experts.

• Ability to organize, prioritize, and work efficiently with minimal supervision in a dynamic environment.

• Demonstrated leadership skills, professional ethics, integrity, and capacity to maintain confidentiality.

• Willingness to travel as needed (10–15%), including attending conferences that may require evening and weekend work.

• Up-to-date knowledge of global dosimetry guidelines and a passion for pioneering alpha-emitting radiotherapeutics is a plus.

• Capability to meet physical demands, including occasionally lifting or moving up to 50 pounds.

🏝️ Benefits

• Additional discretionary incentive cash and stock opportunities.

• Wellbeing support programs.

• Retirement and financial protection benefits.

• Comprehensive medical, dental, vision, life, and disability insurance options.

• Flexible Time Off (FTO) policy with no set accrual limit for U.S.-based exempt employees.

• 11 paid company holidays each year.

• 160 hours of paid vacation annually for new hires who are non-exempt, RayzeBio employees, and employees in Puerto Rico.

• 3 optional holidays available for non-exempt employees, RayzeBio employees, and employees in Puerto Rico.

• Paid sick leave, based on eligibility criteria.

• Up to two paid volunteer days annually, depending on eligibility.

• Flexibility in summer hours.

• Leaves of absence available for medical, personal, parental, caregiver, bereavement, or military needs.

• An annual Global Shutdown between Christmas Day and New Year's Day for eligible employees.

• Reasonable workplace accommodations and ongoing support for individuals with disabilities.