Principal Scientist, Formulation Development

This is a fully remote position, open to applicants in United States.

📋 Description

• Drive formulation strategy across various programs and represent Formulation/Pharmaceutical Development on CMC and multidisciplinary project teams.

• Articulate strategy, risks, trade-offs, and recommendations effectively.

• Design, supervise, and analyze formulation studies for innovative drug candidates, which may include small molecules and/or ASOs.

• Convert study insights into informed development decisions.

• Create phase-appropriate formulations and scalable manufacturing processes.

• Collaborate with Discovery and other departments to facilitate preclinical studies and clinical development.

• Provide scientific guidance for formulation and process development at CDMOs.

• Ensure that external activities adhere to Praxis quality standards, timelines, and clinical manufacturing requirements.

• Write and contribute to formulation development reports and CMC sections of INDs, IMPDs, NDAs, and other related submissions.

• Mentor scientists and external collaborators, unify cross-functional teams, and address challenges impacting program advancement.

⛳️ Requirements

• PhD in pharmaceutical sciences, chemical or biochemical engineering, chemistry, or a closely related scientific field.

• 8+ years of pertinent industry experience.

• Profound comprehension of physicochemical and biopharmaceutical characteristics and their relevance to formulation and drug product design.

• Proven experience in leading formulation development and manufacturing process development from early-stage initiatives through to clinical supply.

• Strong scientific judgment and innovative problem-solving skills in complex development settings.

• Outstanding communication and interpersonal abilities.

• Capacity to influence across various functions and communicate clearly and directly.

• Highly organized and detail-focused, with the capability to manage multiple priorities effectively.

• Self-directed decision-making and accountability in a dynamic environment.

• Traits of curiosity, innovation, urgency, integrity, and confidence.

• Ability to work remotely and readiness to travel as required.

🏝️ Benefits

• 99% of the premium covered for medical, dental, and vision plans.

• Company-funded life insurance, AD&D, and disability benefits.

• Optional plans to customize coverage.

• Dollar-for-dollar 401(k) matching up to 6% on eligible contributions.

• Long-term stock incentives.

• Employee Stock Purchase Plan (ESPP).

• Discretionary quarterly bonuses.

• Extremely flexible wellness benefits.

• Generous paid time off (PTO).

• Paid holidays.

• Company-wide shutdowns.