Lead Bioinformatics Scientist – Oncology

This is a fully remote position, open to applicants in United States.

📋 Description

• Lead the analytical validation strategy for a next-generation sequencing (NGS) assay.

• Design, analyze, and troubleshoot feasibility and performance evaluation studies, including pre-analytical and limit of detection assessments, in collaboration with bench scientists and biostatisticians.

• Drive studies that provide real-world evidence showcasing clinical utility for therapy selection and patient management.

• Select cohorts and perform analyses on plasma mutation calls.

• Create rapid prototypes and pipelines that integrate data from various Natera products.

• Develop algorithms and tools for new products while contributing to the bioinformatics pipeline for production.

• Serve as an internal technical consultant regarding bioinformatics methodologies.

• Collaborate with teams across assay development, engineering, biostatistics, clinical, commercial, regulatory, and laboratory operations.

• Contribute to the preparation of regulatory submissions, clinical study reports, and scientific publications.

⛳️ Requirements

• Master’s degree in bioinformatics or a related discipline with 10 years of post-graduate experience, or a PhD with 5 years of post-graduate experience (preferred).

• In-depth knowledge of bioinformatics tools for NGS, including sequencing quality control and secondary analysis such as variant calling.

• Experience with whole exome sequencing (WES), whole genome sequencing (WGS), and targeted sequencing of tissue and circulating free DNA (cfDNA).

• Familiarity with somatic variant calling, encompassing single nucleotide variants (SNVs), insertions and deletions (indels), copy number variations (CNVs), and fusions.

• Proficient understanding of statistical methods used for evaluating assay performance.

• Strong programming and scripting capabilities in Python, R, and shell scripting.

• Expertise in exploratory data analysis and visualization of complex datasets.

• Comprehensive grasp of NGS workflows from sample extraction to sequencing.

• Exceptional communication skills to effectively engage with wet lab teams and cross-functional partners.

• Ability to work autonomously while juggling multiple objectives and timelines.

• Comfortable with adapting quickly when experimental results necessitate changes to the plan.

• Experience in supporting regulated or clinical-grade assay development, including CLIA/CAP and FDA submissions (preferred).

• Familiarity with clinical genomics and the interpretation of oncology variants (preferred).

• Background in translational or real-world data analysis that integrates clinical and genomic data (preferred).

🏝️ Benefits

• Comprehensive medical, dental, vision, life, and disability insurance plans available for eligible employees and their dependents.

• Free testing services for employees and their immediate families.

• Fertility care benefits offered.

• Leave for pregnancy and baby bonding.

• 401k retirement plan benefits.

• Commuter benefits available.

• Employee referral program incentives.