Director, Clinical Biomarkers – Translational Medicine, Oncology, Solid Tumor Portfolio

This is a fully remote position, open to applicants in United States.

📋 Description

• Oversee the creation and implementation of integrated translational medicine and clinical biomarker strategies from First-in-Human through registration for designated oncology programs.

• Formulate biomarker strategies that enhance patient selection and enrichment, pharmacodynamic evaluations, target engagement, mechanism of action, sensitivity and resistance, dose optimization, along with prognostic and predictive biomarker development.

• Ensure that biomarker plans are scientifically sound, operationally viable, and in alignment with clinical development goals.

• Synthesize and analyze clinical, molecular, pharmacological, and translational datasets to guide program strategy, clinical development choices, and portfolio prioritization.

• Provide scientific leadership for regulatory activities associated with biomarkers.

• Establish and oversee partnerships with academic researchers, contract research organizations, central laboratories, and diagnostic collaborators.

• Represent BeOne Medicines at scientific conferences, external collaborations, and consortium engagements.

• Propel the publication and presentation of translational and biomarker research in peer-reviewed journals and at scientific congresses.

• Collaborate with Discovery Research, Clinical Development, Clinical Pharmacology, Precision Medicine, Bioinformatics, Biostatistics, Regulatory Affairs, Diagnostics, Medical Affairs, and external partners.

• Act as the translational and biomarker lead for assigned oncology programs.

⛳️ Requirements

• At least five years of experience in the pharmaceutical or biotechnology industry focusing on oncology drug development.

• Extensive experience in leading clinical biomarker and translational medicine strategies.

• Proven track record in supporting biomarker strategies throughout Phase I–III oncology clinical development.

• Experience in developing biomarker strategies for targeted therapies, immuno-oncology agents, and/or antibody-drug conjugates.

• Experience in supporting the development of companion diagnostics is highly desirable.

• Preferred experience contributing to regulatory submissions involving biomarkers and precision medicine.

• Profound knowledge in translational oncology and clinical biomarker science.

• Familiarity with next-generation sequencing (NGS), RNA sequencing, ctDNA, multiplex immunohistochemistry, digital pathology, proteomics, flow cytometry, single-cell technologies, emerging multi-omics approaches/data integration, and computational biology.

• Strategic scientific leadership experience in a global matrix environment.

• Strong scientific judgment and ability to make data-driven decisions.

• Exceptional written and verbal communication skills.

• Demonstrated capability to foster productive external scientific collaborations.

• Strong publication history and acknowledged scientific credibility within the oncology field.

• PhD, MD, PharmD, or MD/PhD in Oncology, Molecular Biology, Immunology, Cancer Biology, Pharmacology, or a related scientific area.

• Knowledge of Mandarin is advantageous but not mandatory.

🏝️ Benefits

• Annual bonus plan eligibility for Non-Commercial roles.

• Incentive compensation plan eligibility for Commercial roles.

• Discretionary equity awards.

• Employee Stock Purchase Plan.

• Medical insurance.

• Dental insurance.

• Vision insurance.

• 401(k).

• FSA/HSA.

• Life Insurance.

• Paid Time Off.

• Wellness benefits.