Director, Global Value and Health Economics – Outcomes Research

This is a fully remote position, open to applicants in Pennsylvania.

📋 Description

• Oversee the global and US payer evidence strategy for marketed products within Jazz's neurology portfolio.

• Optimize brand potential, uphold product value, ensure expanded access, and promote evidence generation post-launch.

• Direct HEOR evidence strategies for supplementary regulatory submissions, new indications, line extensions, expanded populations, and innovative formulations/devices.

• Collaborate with Medical Affairs, Clinical Development, and Biostatistics on Phase 3b/4 trials, pragmatic studies, PROs, and HRQoL metrics.

• Formulate indication sequencing and access strategies alongside Market Access.

• Partner on rare disease registries, natural history extensions, and post-authorization safety/efficacy evaluations.

• Create studies focused on comparative effectiveness, adherence, and burden of illness to substantiate product differentiation.

• Co-develop HTA reassessment strategies and analytical packages with EU/INT HEOR teams.

• Manage updates to Global Value Dossiers, systematic literature reviews, and meta-analyses.

• Act as the designated US HEOR expert for assigned inline products.

• Lead AMCP dossiers, unbranded value summaries, and state Medicaid submission dossiers.

• Develop and instruct teams on interactive economic models and responsive scientific presentations.

• Ensure compliance of US HEOR materials with FDAMA Section 114, the 21st Century Cures Act, and FDA HCEI guidance.

• Assess outcomes-based risk-sharing agreements and create frameworks for tracking real-world endpoints.

• Keep abreast of US health policy and prepare evidence plans for ICER and other value assessment organizations.

• Construct and modify cost-effectiveness, cost-utility, budget impact, cost-offset, Markov, partitioned survival, microsimulation, and dynamic budget impact models.

• Represent GVHEOR in IEGP governance and ensure alignment of post-marketing studies with brand objectives.

• Propel post-marketing HEOR publications and share findings at scientific conferences.

• Oversee budgets, external HEOR consultancies, academic collaborators, and CROs.

• Mentor associate directors, managers, and fellows.

⛳️ Requirements

• A Master’s degree (MSc, MS, MPH) or PhD in Health Economics, Outcomes Research, Pharmacoeconomics, or a closely related quantitative discipline.

• A minimum of 7–10 years of experience in HEOR, Global Value, or Health Economics within the biopharmaceutical sector or a leading HEOR consulting firm.

• Extensive background in designing and executing post-marketing HEOR strategies, real-world comparative effectiveness studies, and evidence roadmaps to support label expansions, line extensions, and value defense.

• Thorough working knowledge of the US managed care landscape and global HTA frameworks.

• Proven technical skills in building, adapting, and validating economic models, including Markov, partitioned survival, microsimulation, and dynamic budget impact models.

• Established history of collaborating with US Market Access, Pricing/Contracting, and Payer Field Teams to create compliant customer-facing tools, interactive budget models, and AMCP dossiers.

• Demonstrated understanding of the post-launch evidence challenges related to rare diseases/orphan products.

• Familiarity with major US and global healthcare databases, such as IQVIA, Optum, MarketScan, Medicare SAF, disease-specific registries, and electronic health records.

• Advanced epidemiological methodologies for comparative research.

• Proven ability to collaborate with regional HEOR teams, particularly in the EU/INT.

• Capability to deliver complex technical outputs, including dossiers, models, observational research protocols, and publications.

• Outstanding verbal, written, and presentation abilities.

• Required leadership experience for the launch of at least 2 assets as the US HEOR lead or country-level HTA lead.

• Proven success in leading HEOR strategy and implementing evidence deliverables for marketed pharmaceutical products.

• Experience in conducting post-marketing RWE, patient registry studies, and economic evaluations in rare diseases, specialized medicine, or complex chronic conditions.

• Strong record of peer-reviewed publications in health economics and outcomes research.

• Preferred experience with oncology assets.

🏝️ Benefits

• Discretionary annual cash bonus or incentive compensation.

• Discretionary equity grants through the Long Term Equity Incentive Plan.

• Medical insurance.

• Dental insurance.

• Vision insurance.

• 401k retirement savings plan.

• Flexible paid vacation.