Scientist/Sr. Scientist, Oligo Biology – In Vitro

This is a fully remote position, open to applicants in California.

📋 Description

• Develop experiments in molecular and cellular biology through close collaboration with internal bioinformatics and chemistry teams to facilitate effective in vitro and in vivo screening initiatives.

• Oversee external CROs, encompassing experimental design, prioritization, technical supervision, data analysis, timeline management, and proactive problem-solving to guarantee high-quality and timely project delivery.

• Create and refine siRNAs, ASOs, PMOs, and other innovative nucleotide modalities to improve therapeutic effectiveness.

• Produce and analyze structure-activity relationships (SAR) to inform lead optimization and candidate selection.

• Keep comprehensive technical documentation using Electronic Lab Notebooks (ELNs) and clearly convey experimental strategies, outcomes, and recommendations to diverse scientific audiences.

• Proactively assess emerging technologies and scientific literature to discover novel methods that improve oligonucleotide potency, extrahepatic delivery, durability, and safety.

⛳️ Requirements

• Ph.D. in biology, pharmaceutical sciences, or a related field with 0-6 years of pertinent industry experience, OR M.S. with 2-8 years of industry experience in oligonucleotide therapeutic development.

• In-depth knowledge of siRNA and ASO design principles, cellular mechanisms of action, and chemical modification techniques.

• Familiarity with advanced oligonucleotide delivery technologies, including GalNAc conjugates, lipid conjugates, peptide/antibody-oligonucleotide conjugates (AOCs), or other targeted delivery strategies.

• Practical experience with mammalian cell culture and various transfection techniques.

🏝️ Benefits

• Eligible for target annual bonus

• Equity-based compensation

• Participation in the company’s benefit programs