Principal Scientist, In Vivo Pharmacology, Neurology

This is a fully remote position, open to applicants in California.

📋 Description

• Design and implement in vivo pharmacology studies for Neurology programs involving rodents and non-human primates leading to IND submission.

• Collaborate with toxicology and translational teams to ensure the generation of robust, reproducible, and translatable in vivo pharmacology data.

• Provide insights for dose selection and make informed go/no-go decisions.

• Develop and carry out pharmacodynamic and efficacy evaluations.

• Troubleshoot assays and validate quality-control data from CROs and external collaborators.

• Oversee CRO relationships and track the progress of studies.

• Identify potential study risks and deliver progress updates during team meetings.

• Analyze in vivo pharmacology endpoints, including PK/bioanalysis alongside pharmacodynamic and/or efficacy endpoints.

⛳️ Requirements

• Bachelor's degree with a minimum of 6 years of experience in the biopharmaceutical industry focused on in vivo pharmacology.

• Preferably experienced with small molecules and antisense oligonucleotides (ASOs).

• Strong preference for experience in rare disease or developmental and epileptic encephalopathy (DEE) models.

• Demonstrated strong intellectual curiosity, including regular engagement with the scientific community and familiarity with relevant literature.

• Proven experience and willingness to design pharmacology studies and coordinate external efforts.

• Familiarity with IND-enabling studies.

• Experience in writing regulatory or technical reports.

• Ability to work independently and collaboratively across functions in a dynamic, fast-paced biotech setting.

• Experience in characterizing rodent Neurology models, test article dosing, tissue processing, qPCR, Western blot, and ELISA.

• Proven ability to drive work through CROs and external partners.

🏝️ Benefits

• Patient Days to communicate directly with individuals living with related conditions.

• Access to educational and developmental resources.

• Comprehensive and competitive compensation and benefits package, including performance bonuses, equity, health, welfare, and retirement programs.

• Flexible PTO policy.

• Accelerated career progression for high achievers.

• Potential opportunities to work on various GondolaBio Pharma programs across multiple therapeutic domains.

• Strong commitment to Diversity, Equity & Inclusion.