Scientific Director – tRNA Biotherapeutics

📋 Description

• Establish and implement the scientific vision and R&D roadmap that aligns with the company's milestones.

• Lead the advancement of XtRNA Bio's dual tRNA platform, which includes both elevation and suppression modalities.

• Convert innovative RNA biology into clinically relevant therapeutic strategies.

• Supervise leading preclinical programs in targeted indications, focusing on tRNA elevation in neuromuscular disorders, especially CMT2D, and tRNA suppression in respiratory conditions, particularly CF.

• Oversee the optimization of AAV-tRNA constructs, which encompasses vector design, capsid selection, and delivery strategies.

• Propel the development of synthetic tRNA delivery systems aimed at the respiratory tract.

• Manage in vivo and in vitro research, including studies using rodent and NHP models, biomarker development, and functional endpoints.

• Lead IND-enabling studies that include biodistribution, toxicology, and dose-finding assessments.

• Identify and evaluate potential clinical applications for the XtRNA platform.

• Continue to refine and enhance our delivery modalities.

• Collaborate with relevant academic partners for proof-of-concept studies.

• Develop and support a dedicated Scientific Advisory Board.

• Collaborate with teams in CMC and vector manufacturing, regulatory and clinical strategies, intellectual property, and business development.

• Ensure alignment of scientific execution with fundraising efforts, partnerships, and corporate milestones.

• Foster a culture of scientific excellence, rigor, and innovation.

• Interact with external collaborators, key opinion leaders, and members of the Scientific Advisory Board.

• Build, mentor, and motivate a high-performing multidisciplinary R&D team over the long term.

• Present scientific advancements to investors, partners, and at scientific conferences.

• Contribute to publications, patents, and enhance company visibility.

⛳️ Requirements

• PhD (or equivalent) in Molecular Biology, Genetics, Neuroscience, or a related discipline.

• 8–12+ years of experience in early-stage biotech or pharmaceutical settings, with a focus on progressive scientific leadership roles.

• Extensive knowledge in RNA biology and/or translation mechanisms.

• Experience in gene therapy, particularly with AAV-based delivery systems.

• Background in neuromuscular or rare genetic diseases.

• Demonstrated experience in AAV vector design, delivery, and analytics.

• Familiarity with LNP delivery modalities.

• Experience with preclinical models (rodent; NHP experience is an advantage).

• Proficiency in molecular and cellular assays (RNA-seq, qPCR, histology, biomarkers).

• Proven track record of advancing programs towards IND-enabling stages.

🏝️ Benefits

• Primarily equity-based compensation.

• Modest base salary until fundraising efforts are successful.